What setting would you use for supports on a wireframe model?
Great question:
(A) If oriented correctly the wireframe can support quite a bit of itself so I try to rotate it until the wires are going diagnol to create an angle that works on my printers. 45 degree overhang works great for me so this would be an example:
(B) Select this brush icon and paint where you want the supports:
In my example I painted them here:
(C) Now you can use any kind of support you want, grid, organic, etc. Off to the left change the supports to "enforcers only" this will use the painted on data to add supports: